Table 2. Subgroup analysis results of included studies.
| Sensitivity (95% CI) | Specificity (95% CI) | DOR (95% CI) | SROC(AUC±SE) | |
|---|---|---|---|---|
| Type of samples | ||||
| Serum | 0.78(0.77–0.80) | 0.80(0.79–0.82) | 17.11(12.44–23.54) | 0.87±0.01 |
| P/I2 | < 0.0001/82% | < 0.0001/82.1% | < 0.0001/82% | - |
| Plasma | 0.74(0.73–0.75) | 0.74(0.72–0.75) | 10.80(7.89–14.79) | 0.83±0.02 |
| P/I2 | < 0.0001/92.9% | < 0.0001/87.7% | < 0.0001/84.1% | - |
| Type of miRNAs | ||||
| miR-155-5p | 0.71(0.67–0.75) | 0.82(0.76–0.86) | 11.90(4.07–34.76) | 0.85±0.08 |
| P/I2 | 0.0004/87.2% | 0.0213/74.0% | 0.0020/83.9% | - |
| miR-21 | 0.86(0.82–0.89) | 0.60(0.55–0.65) | 8.05(2.45–26.40) | 0.67±0.14 |
| P/I2 | < 0.0001/91.3% | 0.0169/66.8% | < 0.0001/89.6% | - |
| miR-223-3p | 0.70(0.66–0.74) | 0.81(0.77–0.85) | 8.82(4.41–17.66) | 0.78±0.06 |
| P/I2 | < 0.0001/86.6% | < 0.0001/90.2% | 0.0048/73.3% | - |
| miR-146a | 0.77(0.73–0.81) | 0.56(0.51–0.61) | 5.86(2.42–14.19) | 0.69±0.11 |
| P/I2 | 0.0001/85.9% | 0.0749/56.6% | 0.0002/85.0% | - |
| miR-125a | 0.81(0.77–0.84) | 0.67(0.63–0.71) | 10.54(2.88–38.56) | 0.74±0.12 |
| P/I2 | < 0.0001/95.8% | < 0.0001/87.9% | < 0.0001/94.4% | - |
CI = confidence interval, DOR = diagnostic odds ratio, SROC = summary receiver operating characteristic curves value, AUC = area under the curve, SE = standard error.