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. 2023 Feb 8;14:1082911. doi: 10.3389/fgene.2023.1082911

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Copyright © 2023 Luo, Liu, Bian and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA-seq of the mandibular tissue from E18.5 Six1 ^−/− and Six1 ^+/+ embryos. (A) Volcano plots show differentially expressed genes between Six1 ^−/− and Six1 ^+/+ mandibular samples. (B) RT-qPCR analysis of Opn, Ocn, Osx and Etv1 in Six1 ^−/− and Six1 ^+/+ mandibular tissues at E18.5. (C) GO enrichment analysis of genes significantly downregulated in Six1 ^−/− mandible. (D) Immunofluorescence staining of OPN in mandible of Six1 ^−/− and Six1 ^+/+ embryos at E16.5 and E18.5.