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. 2023 Feb 20;12(1):2178238. doi: 10.1080/22221751.2023.2178238

Figure 8.

Figure 8.

SARS-CoV-2 infection decreases Nsun2 expression levels and activates innate immunity responses in K18-hACE2 KI mice. (a) qPCR analysis of Nsun2, Irf3, Ifnb1, Isg15 and Cxcl10 mRNA in lungs from SARS-CoV-2 WT strain infected K18-hACE2 KI mice (n = 5) or uninfected K18-hACE2 KI mice (n = 5), injected intranasally for 48 h with SARS-CoV-2 WT strain (250 PFU per mouse). (b) qPCR analysis of Nsun2, Irf3, Ifnb1, Isg15 and Cxcl10 mRNA in lungs from SARS-CoV-2 BA.1 omicron variant infected K18-hACE2 KI mice (n = 5) or uninfected K18-hACE2 KI mice (n = 5), injected intranasally for 48 h with SARS-CoV-2 WT strain (8000 PFU per mouse). NS, not significant for P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001.