Table 1.

Effect of ferulic acid derivatives on the various pathological pathways involve in AD.

Compound No.	Classification	The major targets	Activity (µM)	References
1	Ferulic acid derivatives	AChE inhibitory activity	IC50 (hAChE) = 5.74	19
2		MAO-B inhibitory activity Inhibits self-induced aggregation of Aβ1-42	IC50 (hMAO-B) = 0.32	20
3			IC50 (hMAO-B) = 0.56
4			IC50 (hMAO-B) = 0.54
5			IC50 (hMAO-B) = 0.73
6			IC50 (hMAO-B) = 0.86
7		Inhibits self-induced Aβ Aggregation and the efficacy of AChE	IC50 (hAChE) = 0.0192 IC50 (hBChE)= 0.66	21
8		HDAC6 inhibitory activity DPPH radical scavenging ability Cu2+chelating ability Preventing Aβ25 − 35 induced spatial work and long-term memory dysfunction	IC50 (HDAC6)=0.0307	22
9	Coumarin derivatives	MAO-B inhibitory activity	IC50 (hMAO-B) = 0.00507	23
10			IC50 (hMAO-B) =0.0042
11			IC50 (hMAO-B) =0.00394
12		Inhibit AChE and BChE	IC50 (hBChE) = 30.3	24
13			IC50 (hBChE) = 29.2
14			IC50 (hBChE) = 37.2
15			IC50 (hBChE) = 50.1
16		Inhibit AChE and MAO-B Reversing cognitive dysfunction in AD mice induced by scopolamine Inhibit AChE and BChE	IC50 (hAChE) = 0.0068	25
17			IC50 (hAChE) = 0.114
18			IC50 (hBChE) = 30.2	26
19			IC50 (hBChE) = 0.363
20	Eugenol derivatives	MAO-A inhibitory activity	IC50 (hMAO-A) = 5.989	27
21			IC50 (hMAO-A) = 7.348
22		MAO-B inhibitory activity	IC50 (hMAO-B) = 7.494
23			IC50 (hMAO-B) = 9.183