Table 3.

Effect of terpenoids derivatives on the various pathological pathways involve in AD.

Compound No.	Classification	The major targets	Activity (µM)	References
36–44	Triptolide derivatives	Protect nerve cells from Aβ1-42 damage Inhibits LPS induce TNF	_	51
45/46	Andrographolide derivatives	Inhibits LPS induced NO production, iNOS expression and proinflammatory cytokine TNF- α and IL-6 Protect neurons from microglia mediated neurotoxicity Promotes NGF induced axon growth in PC12 cells	_	52
47-49		β-Secretase inhibitors AChE inhibitory activity	_	53
50	Glycyrrhetinic acid derivatives	AChE inhibitory activity	IC50 (hAChE) = 3.43	54
51			IC50 (hAChE) = 5.39
52			IC50 (hAChE) = 6.27
53			IC50 (hAChE) = 8.68
54		BChE inhibitory activity	IC50 (hBChE) = 5.43	55
55			IC50 (hBChE) = 9.81
56	Safranal derivatives	MAO-A inhibitory activity MAO-B inhibitory activity	IC50 (hMAO-A) = 9.93 IC50 (hMAO-B) = 0.0091	56