Table 5.

Effect of alkaloid derivatives on the various pathological pathways involve in AD.

Compound NO.	Classification	The major targets	Activity	References
64	Piperine derivatives	Inhibiting apoptotic cell death induced by IBO Inhibited the interaction between Keap1 and Nrf2	_	85
65		Inhibits the increase of Bax/Bcl2 ratio protects hippocampal neurons Inhibits the activation of NLRP3 inflammatory bodies in hippocampus Reduces Aβ1-42 Induced neurotoxicity in SH-SY5Y cells	_	90
66	Harmine derivatives	Inhibits GSK-3β and DYRK1A, Inhibits oka induced tau hyperphosphorylation in SH-SY5Y cells,	IC50 (GSK-3β) = 71 nM IC50 (DYRK1A) = 103 nM	91
67		AChE inhibitory activity BChE inhibitory activity Inhibits GSK-3β	IC50 (hAChE) = 0.27 µM IC50 (hBChE) = 20.82 µM IC50 (GSK-3β) = 6.78 µM	92
68	Oxymatrine derivatives	Protect PC12 cells from Aβ induced damage Inhibition of LPS induced NO	_	93
69
70