Table 1.
Study population baseline eharaeteristies and clinical presentation.
| Tota (N = 646) |
SGLT2-I users (N = 111) |
Non-SGLT2-I users (N = 535) |
P-value | |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Age, years | 70 [61–79] | 66 [59–73] | 72 [62–80] | <0.001 |
| Male Sex, n (%) | 498 (77.1) | 90 (81.1) | 405 (75.7) | 0.222 |
| BMI, kg/m2 | 27.7 [25 – 31.3] | 27.1 [24.6–30] | 27.7 [25–31.4] | 0.245 |
| BSA, m2 | 1.94 [1.8–2.1] | 1.96 [1.8 – 2.03] | 1.93 [1.78 – 2.1] | 0.261 |
| Smoking, n (%) | 370 (57.3) | 67 (60.4) | 303 (56.6) | 0.470 |
| Hypertension, n (%) | 541 (83.7) | 98 (88.3) | 443 (82.8) | 0.154 |
| Dyslipidemia, n (%) | 508 (78.6) | 90 (81.1) | 418 (78.1) | 0.490 |
| PAD, n (%) | 82 (12.7) | 16 (14.4) | 66 (12.3) | 0.550 |
| COPD, n (%) | 90 (13.9) | 15 (13.5) | 75 (14) | 0.889 |
| CKD, n(%) | 58 (9) | 10 (9) | 47 (8.8) | 0.886 |
| Previous TIA/CVA, n (%) | 52 (8) | 10 (9) | 42 (7.9) | 0.683 |
| Previous AMI, n (%) | 169 (26.2) | 30 (27) | 136 (25.4) | 0.724 |
| Previous PCI, n (%) | 183 (28.3) | 35 (31.5) | 144 (26.9) | 0.322 |
| Clinical presentation | ||||
| STEMI, n (%) | 309 (47.8) | 52 (46.8) | 257 [48] | 0.819 |
| Time symptoms–balloon (STEMI), hours | 3 [2–5] | 3 [2–6] | 3 [2–5] | 0.648 |
| Time symptoms–balloon < 24 h (NSTEMI) | 207 (61.4) | 39 (66.1) | 175 (62.9) | 0.647 |
| SBP, mmHg | 140 [125–160] | 140 [125–155] | 140 [125–160] | 0.639 |
| DBP, mmHg | 80 [70–90] | 83 [70–90] | 80 [70–90] | 0.551 |
| HR, bpm | 81 [70–94] | 75 [68–86] | 83 [72–95] | <0.001 |
| Angina, n (%) | 466 (72.1) | 80 (72.1) | 386 (72.1) | 0.987 |
| NYHA> 2, n (%) | 113 (17.5) | 16 (14.4) | 101 (18.9) | 0.266 |
| Killip Class ≥ 2, n (%) | 135 (20.9) | 18 (16.2) | 117 (21.9) | 0.183 |
| VT/VF, n (%) | 21 (3.3) | 2 (1.8) | 19 (3.6) | 0.344 |
| AF, n (%) | 58 (9) | 9 (8.1) | 49 (9.2) | 0.725 |
Continuous variables are presented as mean±SD or as median [IQR]; while categorical variables as number (%).
Abbreviations: BMI=Body Mass Index; BSA=Body Surface Area; CKD=chronic kidney disease with 30 <GFR< 60 ml/min; PCI=Pereutaneous Coronary Intervention; AF=atrial fibrillation; ACEI=Angiotensin-converting enzyme; ARB = Angiotensin II Receptor Blockers; CCB=Caleium Channel Blockers; BB=B-bloekers; GFR=Glomerular Filtration Rate. STEMI=ST-segment Elevation Myocardial Infarction; NSTEMI=non-ST segment Elevation Myocardial Infarction; SBP=systolie blood pressure; DBP=diastolie blood pressure; HR=heart rate; NYHA=New York Heart Association; VT=Ventrieular Tachycardia; VF=Ventricular Fibrillation; AF=Atrial Fibrillation.