Table 5.
Univariate and multivariable analysis. Predictors of cardiovascular death, HF hospitalization, and MACE.
| Cardiovascular Death |
HF Hospitalization |
MACE |
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis |
Multivariate analysis |
Univariate analysis |
Multivariate analysis |
Univariate analysis |
Multivariate analysis |
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| Variables | HR | 95 %CI | p-value | HR | 95 %CI | p-value | HR | 95 %CI | p-value | HR | 95 % CI | p-value | HR | 95 % CI | p-value | HR | 95 % CI | p-value |
| Age, years | 1.03 | 1.01–1.05 | 0.004 | 1.02 | 0.99 – 1.05 | 0.085 | 1.01 | 0.98–1.02 | 0.863 | – | – | – | 1.02 | 0.99–1.03 | 0.053 | – | – | – |
| Gender, male | 1.42 | 0.86–2.34 | 0.167 | – | – | – | 0.80 | 0.49–1.29 | 0.357 | – | – | – | 1.13 | 0.81–1.59 | 0.467 | – | – | – |
| Admission BGL | 1.01 | 1.01–1.02 | 0.009 | 1.01 | 0.99 – 1.01 | 0.776 | 1.01 | 0.99–1.01 | 0.623 | – | – | – | 1.01 | 0.99–1.02 | 0.098 | – | – | – |
| Admission CRP | 1.01 | 0.99–1.01 | 0.292 | – | – | – | 0.99 | 0.97–1.02 | 0.606 | – | – | – | 1.01 | 0.99–1.02 | 0.094 | – | – | – |
| Peak Hs-TnI, ng/L | 1.01 | 1.01–1.03 | <0.001 | 1.01 | 1.01 – 1.03 | 0.018 | 1.01 | 1.01–1.03 | 0.023 | 1.01 | 1.01–1.03 | 0.068 | 1.01 | 1.01–1.02 | 0.026 | 1.01 | 0.99–1.00 | 0.238 |
| NSTEMI | 0.63 | 0.40–1.02 | 0.054 | – | – | – | 0.86 | 0.59–1.26 | 0.441 | – | – | – | 0.90 | 0.67–1.21 | 0.482 | – | – | – |
| Complex PCI | 1.15 | 0.65–2.04 | 0.620 | – | – | – | 1.35 | 0.85–2.15 | 0.200 | – | – | – | 1.34 | 0.94–1.91 | 0.101 | – | – | – |
| Complete Rev. | 0.32 | 0.20–0.51 | <0.001 | 0.51 | 0.30–0.89 | 0.017 | 0.39 | 0.26–0.58 | <0.001 | 0.38 | 0.25–0.57 | <0.001 | 0.30 | 0.22–0.40 | <0.001 | 0.37 | 0.26–0.51 | 0.001 |
| Discharge moderate-to-severe MR | 2.07 | 1.55–2.77 | <0.001 | 1.48 | 1.05–2.09 | 0.025 | 1.28 | 1.06–1.69 | 0.040 | 1.17 | 0.89–1.55 | 0.251 | 1.48 | 1.21–1.82 | <0.001 | 1.29 | 1.04–1.59 | 0.018 |
| Discharge crea. | 1.24 | 1.14–1.35 | <0.001 | 1.33 | 1.17–1.52 | <0.001 | 1.11 | 0.99–1.26 | 0.061 | – | – | – | 1.22 | 1.14–1.30 | <0.001 | 1.13 | 1.04–1.22 | 0.003 |
| SGLT2-I | 0.33 | 0.12–0.90 | 0.031 | 0.53 | 0.19–1.52 | 0.237 | 0.45 | 0.21–0.97 | 0.038 | 0.46 | 0.21 – 0.98 | 0.041 | 0.51 | 0.29–0.87 | 0.014 | 0.57 | 0.33–0.99 | 0.039 |
Abbreviations: BGL=blood glucose level; CRP=C-reactive Protein; Hs-TnI=high sensitivity Troponin I; NSTEMI=non-ST segment Elevation Myocardial Infarction; PCI=Primary Percutaneous Coronary Intervention; Complete Rev.=complete revascularization. MR=mitral regurgitation; HF=Heart Failure; MACE=major adverse cardiovascular events.