Table 1.
Variants of concerns | Synonyms | Mutations |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
ORF1ab | Spike | ORF3a | ORF3b | E | M | ORF6 | ORF7a | ORF7b | ORF8 | N | ||
Alpha | B.1.1.7 |
Nsp3: T1001I, A1708D, I2230T Nsp6: Del 3675-3677 RdRp: P4715L |
Del 69-70 Del 144 N501Y A570D D614G P681H T716I S982A D1118H |
– | – | – | – | – | – | – | R52I Q27 Y73C |
D3L S235F |
Beta | B.1.351 |
Nsp1: T265I Nsp3: K1655 N Nsp6: Del 3675-3677 3CL: K3353R |
L18F D80A D215G K417 N N501Y D614G A701V |
– | – | P71L | – | – | – | – | – | T205I |
Gamma | P.1 |
Nsp3: S1188L, K1795Q Nsp6: Del 3675-3677 Nsp13: E5665D RdRp: P4715L |
L18F T20 N P26S D138Y K417 N/T E484K N501Y D614G H655Y T1027I V1176F |
S253P | – | – | – | – | – | – | E92K | P80R |
Delta | B.1.617 |
Nsp3: A1306S, P2046L, P2287S 3CL: K3255R Nsp12: P5715L, G5063S Nsp13: P4501L Nsp14: A6019V |
T19R Del 156 Del 157 R158G L452R T478K D614G P681R D950 N |
S26L | – | – | I82L | – | V82A T120I |
– | – | D63G R203 M D377Y |
Omicron | BA.1 |
Nsp3: K856R, SL2083I, A2710T 3CL: T3255I, P3395H Nsp6: Del 3674–3676, I3758V RdRp: P4715L Nsp14: I5967V |
A67V Del 69–70 T95I GVYY142-145D NL211-212I ins214EPE G339D S371L S373P S375F K417 N N440K G446S S477 N T478K E484A Q493R G496S Q498R N501Y Y505H T547K D614G H655Y N679K P681H N764K D796Y N856K Q954H N969K L981F |
– | – | T9I | D3G Q19E A63T |
– | – | – | – | P13L Del 31-33 R203K G204R |
BA.2 |
Nsp1: S135R Nsp3: T842I, G1307S Nsp4: L3027F, T3090I, L3201F Nsp6: Del 3675-3677 3CL: T3255I, P3395H RdRp: P4715L Nsp13: R5716C Nsp14: I5867V Nsp15: T6564I |
T19I LPPA24-27S G142D V213G G339D S371F S373P S375F T376A D405 N R408S K417 N N440K S477 N T478K E484A Q493R Q498R N501Y Y505H D614G H655Y N679K P681H N764K D796Y Q954H N969K |
T223I | – | T9I | Q19E A63T |
D61L | – | – | S84L | P13L Del 31-33 R203K G204R S413R |