Fig. 1.

Descriptive and mutational analyses of MPXV B.1 lineages. (A) Geographical distribution and circulation of the current MPXV outbreak 2022. The colored arrows indicate the first presumptive dispersal routes of the B.1 lineages (B) Temporal variations in the proportions of genomes of the B.1 lineages. (C) Mutational analysis of nonsynonymous changes at the amino acid level between the lineages and clades of MPXV. The purple color represents the unique substitutions shared between the genomes of B.1 lineages analyzed (N = 1118), the green color the substitutions shared between MPXV lineages/clades, and the yellow color represent the substitutions considered unique for each taxa. In red, it highlights the amino acid modifications associated with the action of the APOBCE3 enzyme. (D) Proportion of MPXV genomes that have the unique nucleotide mutations of the B.1 lineages. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)