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. 2023 Feb 8;614(7949):767–773. doi: 10.1038/s41586-023-05710-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a, Venn diagram of RNA-sequencing data showing significantly upregulated ISGs in crisis of IMR90^E6E7, WI38^SV40LT, or both types of fibroblasts as compared with growing cells (PDs are indicated in Extended Data Fig. 1b). Upregulated ISGs with a fold change > 1.5 and false-discovery rate < 0.05 are shown. The complete list of ISGs includes 390 genes and is based on the RNAseq analysis of 5 cell types transfected with 20 viruses from 9 virus classes⁵¹. One experiment was performed. b, Heat maps representing RNA-sequencing data of upregulated ISGs (n = 61) in crisis of both types of fibroblasts as in a (lower panel). c, Graphical representation of the enrichment of gene ontology terms for the genome-wide CRISPR/Cas9 knock-out screen. sgRNAs with log₂ fold change > 2 are used. The top 20 biological processes are shown. Two independent experiments were performed. Abbreviations: DEGs: differentially expressed genes; sgRNA: single guide RNA; GO: gene ontology; ISGs: interferon stimulated genes, PD: population doubling.

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