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. 2023 Feb 8;614(7949):742–751. doi: 10.1038/s41586-022-05688-9

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© The Author(s), under exclusive licence to Springer Nature Limited 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — (a) Force-directed graph of 5,610 myeloid progenitor cells from Setty et al.⁶⁷ with all clusters labelled. MPP = Multipotent Progenitor; GMP = Granulocyte–Monocyte Progenitor; Gran = Granulocyte; MEP = Megakaryocyte–Erythrocyte Progenitor; Mk = Megakaryocyte. (b) Marker gene expression (log-transformed UMI) projected onto the force-directed graph. PROCR = MPP marker; EPOR = Erythrocyte marker; ITGA2B = Mk marker; FLT3 = LP marker; MPO = Gran/Mo marker; MS4A2 = Baso marker. (c) Pseudotime values projected onto the force-directed graph. (d) Differentiation vector calculated from the pseudotime gradient. ME and GM lineages are highlighted. (e) CSF1R and CEBPE gene expression projected onto the force-directed graph. The right panel is a magnified area of the GM lineage. The CSF1R is a monocyte marker, and CEBPE is a granulocyte marker. (f) Early lineage bifurcation between monocytes and granulocytes is observed on the force-directed graph.