Table 1.

Potential targets and approaches for various collagens and cadherins targeting

Potential targets	Type of proteins targeted	Drug and delivery approaches	Ref.
HSP47	Collagen-I, II, III, IV, V, XI	Liposomes, silica nanoparticles, small molecules inhibitors, siRNA	81 and 150–154
Lysyl oxidase	Collagen-I, II, III, IV, V, IX, XI	Antibody-siRNA, inhibitory monoclonal antibody, β-aminopropionitrile	81 and 155–158
TANGO1	Collagen-I, II, III, IV, VII, IX	COPII and melanoma inhibitory activity member 3 carrier protein from the endoplasmic reticulum	81, 159 and 160
FKBP10	Collagen-I, III, V, VI	siRNA, nintedanib, or pirfenidone	81, 161 and 162
LARP6	Collagen-I, III	mRNA, small molecule inhibitors, TPI-2659, TPI-2435	163–165
Hepatic stellate cells	Collagen-I, III, VI	Albumin nanocarriers, IFN-α1b liposomes, polyetherimine (RcP) nanoparticles, oligonucleotides delivery, RGD modified polymerosomes	166–170
Cadherins	Cadherin-11	Anti-cadherin-11 antibody, repurposed celecoxib	54, 171 and 172
Cadherins	Cadherin-11, E-cadherin	siRNA, miR-199a-5p, miR-214–3p, miR-373, lipid nanoparticles	173‒176