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. 2023 Feb 22;13:3112. doi: 10.1038/s41598-023-30260-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PPI network and functional modules. (A) PPI network. left: 436 nodes and 2888 edges. The outer circle represents interaction proteins whereas the inner circle represents candidate genes. right: Among 22 candidate genes, FGA and VWF have the highest Degree, and interact with MPRIP. The color indicates a change in Degree. The darker color indicates greater Degree and more important function node in the network (B) VWF, MPRIP and FGA belong to the same function module. yellow, red and blue represents germline mutation, somatic mutation, and interaction protein, respectively.