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. 2023 Feb 22;14(2):149. doi: 10.1038/s41419-023-05667-6

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© The Author(s) 2023, corrected publication 2023

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Fig. 4 — A The protein and mRNA levels of VHL were detected in MALAT1-depleted HNSCC cells by using western blot and qPCR assays. Data, mean ± SD, **P < 0.01, ***P < 0.001. B The abundance of EZH2, p-STAT3 and p-Akt was measured in SCC15 and UM1 cells transiently transfected with si-EZH2 and negative control, respectively. The protein expression of VHL was elevated using immunoblotting assay in HNSCC cells treated with stattic (C) and MK2206 (D). E The results of western blot revealed that EZH2 overexpression rescued the effect of si-MALAT1 on p-STAT3, p-Akt, and VHL, respectively. oe overexpression. F The results of western blot showed that si-VHL mitigated the inhibition of si-MALAT1 on β-catenin and NF-κB pathways. NC negative control. si-M si-MALAT1.