Table 2.

Inclusion criteria and exclusion criteria.

Patients who meet the following requirements will be considered for inclusion:

Patients will be excluded if they have:

(1) Diagnosed as advanced breast cancer and PN symptoms occur after using UTD1. The patient had no obvious PN symptoms before using UTD1; (2) Over 18 and under 70 years old, and the expected survival time was ≥6 months; (3) Have daily living ability and can complete all questionnaire investigation; (4) No serious heart, brain, kidney, and other diseases, KPS score >70; (5) Clear consciousness without severe mental illness or cognitive impairment; (6) Sign the written informed consent form.

(1) Diagnoses as other severe systemic diseases (e.g., cardiovascular disease, acute infectious disease, hematopathy, et al.); (2) Diagnoses as severe mental disorders, like schizophrenia; (3) PN caused by other diseases, such as diabetic peripheral neuropathy; (4) Alcohol and/or other drug abuse or dependence; (5) Pregnant and lactating women; (6) Participating in other clinical trials.

PN, peripheral neuropathy; UTD1, Utidelone; KPS, Karnofsky performance status.