Table 1.
Drugs of targeting mitochondrial proteins
| Mitochondria protein-target drug | Target protein | Cell death mechanism | Reference |
|---|---|---|---|
| AZD-5991 | BCL-2 family | Apoptosis induction | Tron et al. (2018) |
| BM-1197 | Sun et al. (2019) | ||
| Obatoclax (GX15-070) | Cournoyer et al. (2019) | ||
| S63945 | Kotschy et al. (2016) | ||
| TW-37 | Ahn et al. (2019) | ||
| Navitoclax (ABT-263) | Ashkenazi et al. (2017) | ||
| Venetoclax (ABT-199) | |||
| 2-deoxyglucose (2-DG) | Hexokinase II | Inhibition of cell metabolism | Zhao et al. (2019) |
| 3-bromopyruvate (3BP) | Lis et al. (2016) | ||
| Benitrobenrazide | Zheng et al. (2021) | ||
| FV-429 | Zhou et al. (2016) | ||
| AG-120 | Isocitrate dehydrogenase I, II | Inhibition of cell metabolism | Golub et al. (2019) |
| AG-221 | |||
| AGI-5198 | |||
| AGI-7680 | |||
| Enasidenib (AG-221) | |||
| Ivosidenib (AG-120) | |||
| Metformin | Complex I | ROS accumulation | Fontaine et al. 2018 |
| Rotenone | Li et al. (2003) | ||
| Alpha-tocopheryl succinate (α-TOS) | Complex II | ROS accumulation | Dong et al. (2008) |
| Atpenin A5 | Kluckova et al. (2013) | ||
| MitoVES | Yan et al. (2015) | ||
| Thenoyltrifluoroacetone | Zhang and Fariss (2002) |