Table 2.
Serum and urinary biochemistry in WT, Alb-hKL, and Pod-hKL mice 7 days after NTS injection compared to WT-control.
| Control | NTS | |||
|---|---|---|---|---|
| WT, n = 14 | WT, n = 16 | Alb-hKL, n = 12 | Pod-hKL, n = 9 | |
| Serum | ||||
| Creatinine (mg/dL) | 0.153 ± 0.04 | 0.228 ± 0.02#### | 0.210 ± 0.02## | 0.231 ± 0.06### |
| Calcium (mg/dL) | 9.49 ± 2.46 | 6.92 ± 1.21### | 6.63 ± 1.08### | 7.86 ± 0.66 |
| Phosphate (mg/dL) | 10.51 ± 1.67 | 9.49 ± 1.83 | 9.64 ± 1.36 | 8.29 ± 0.97# |
| Klotho (ng/mL) | 2.34 ± 1.97**** | 1.78 ± 1.15**** | 1.3.104 ± 6.9.103 | 8.71 ± 4.69**** |
| Intact Fgf23 (pg/mL) | 153.9 ± 55.5 | 290.5 ± 102.5# | 426.8 ± 146.5#### | 507.5 ± 239.8 ####,@@ |
| Urine | ||||
| FECa (%) | 0.43 ± 0.24 | 0.90 ± 0.59 | 1.26 ± 0.97 | 1.27 ± 1.03 |
| FEPi (%) | 0.53 ± 0.49 | 0.24 ± 0.33 | 0.27 ± 0.37 | 0.12 ± 0.18 |
| U-Klotho/U-Creatinine (pg/mg) | 102.1 ± 37.7 | 95.1 ± 13.1 | 177.0 ± 152.9 | 102.1 ± 33.5 |
FECa fractional excretion of calcium, FEPi fractional excretion of phosphate.
#p < 0.05.
##p < 0.01.
###p < 0.001.
####p < 0.0001 vs. Control WT.
@@p < 0.01 vs. NTS WT.
****p < 0.0001 vs NTS Alb-hKL.