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. 2023 Feb 22;14:977. doi: 10.1038/s41467-023-36571-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, b IFA and western blot detection of complemented HA-TgKelch13 in the AID-Kelch13 line by growth in ±IAA for 24 h. Actin served as a control. Scale bar = 5 μm. c Plaque formation by the AID-K13 and complementation lines grown in ±IAA for 7 days. Scale bar = 0.5 cm. d Survival of mice infected with TIR1, AP2αc-AID, EPS15-AID, AID-K13, tKD and the complementation line (AID-K13/TgK13) in the absence (with vehicle) and presence of auxin. Mice survival was monitored for 20 days post-infection. One representative result was shown from three independent experiments, and 100 parasites were used per mouse for infection. Survival data were analyzed by the Gehan-Breslow-Wilcoxon test, comparing to the TIR1 +IAA. ***p < 0.0001, and p values are provided; not significant for AID-K13/TgK13 +IAA vs. TIR +IAA.