TABLE 3.
Recent approaches of oridonin optimizations (modifications of D-ring - α, β-unsaturated ketone).
| No. | Chemical structure | In vitro activity (µM) | Reference |
|---|---|---|---|
| 16 |
|
BEL-7402 IC50 = 3.21 | Shen et al. (2018) |
| HCT-116 IC50 = 1.05 |
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