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Recent approaches of oridonin optimizations (transformations of the skeletal structure).
| No. | Chemical structure | In vitro activity (µM) | References |
|---|---|---|---|
| 17 |
|
BEL-7402 IC50 = 1.39 | Li et al. (2013a) |
| K562 IC50 = 0.39 | |||
| 18 |
|
BEL-7402 IC50 = 0.87 | Li et al. (2013b) |
| K562 IC50 = 0.24 |
