REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
mouse anti-βIII-tubulin	BioLegend	Cat#801201; RRID:AB_2313773
rabbit anti-Sox2	Millipore	Cat#AB5603; RRID:AB_2286686
mouse anti-Ki67	Abcam	Cat#ab15580; RRID:AB_443209
rabbit anti-Pax6	Biolegend	Cat#901301; RRID:AB_2565003
rabbit anti-Tbr2	Abcam	Cat#ab23345; RRID:AB_778267
mouse anti-Ki67	BD Pharmingen	Cat#550609; RRID:AB_393778
rabbit anti-Mcm2	Abcam	Cat#ab4461; RRID:AB_304470
mouse anti-Sox2	Abcam	Cat#ab79351; RRID:AB_10710406
goat anti-DCX	Santa Cruz biotechnology	Cat#sc-8066; RRID:AB_2088494
rabbit anti-Tbr1	Abcam	Cat#ab31940; RRID:AB_2200219
mouse anti-Satb2	Abcam	Cat#ab51502, RRID:AB_882455
donkey anti-rabbit Alexa Fluor 555	Thermo Fisher Scientific	Cat#A-31572; RRID:AB_162543
goat anti-mouse Alexa Fluor 488	Thermo Fisher Scientific	Cat#A-32723; RRID:AB_2633275
goat anti-mouse Alexa Fluor 555	Thermo Fisher Scientific	Cat#A-21422; RRID:AB_2535844
donkey anti-rabbit Alexa Fluor 647	Thermo Fisher Scientific	Cat#A-31573; RRID:AB_2536183
goat anti-mouse Alexa Fluor 647	Thermo Fisher Scientific	Cat#A-32728; RRID:AB_2633277
donkey anti-goat Alexa Fluor 647	Thermo Fisher Scientific	Cat#A-21447; RRID:AB_141844
Hoechst 33342	Cell Signaling	Cat#4082; RRID:AB_10626776
rabbit anti-p-CREB (S133)	Cell Signaling	Cat#9198S; RRID:AB_2561044
mouse anti-CBP	Santa Cruz Biotechnology	Cat#sc-7300; RRID:AB_626817
rabbit anti-paPKCζ/ι (T410/403)	Cell Signaling	Cat#9378; RRID:AB_2168217
mouse anti-CREB	Cell Signaling	Cat#9104S; RRID:AB_490881
mouse anti-aPKCζ/ι	BD Pharmingen	Cat#610175; RRID:AB_397574
HRP-conjugated goat anti-mouse	Cell Signaling	Cat#7076; RRID:AB_330924
HRP-conjugated goat anti-rabbit	Cell Signaling	Cat# 7074; RRID:AB_2099233
Chemicals, peptides, and recombinant proteins
1000ppm MeHg(II)Cl	Alfa Aesar	Cat#33553
1,1-Dimethylbiguanide hydrochloride	Sigma-Aldrich	Cat#D150959
Metformin hydrochloride	Sigma-Aldrich	Cat#PHR1084
Critical commercial assays
Proximity ligation assay	Sigma-Aldrich	Cat#DUO92101
In Situ Cell Death Detection Kit	Sigma-Aldrich	Cat#11684817910
Deposited data
scRNA-seq datasets	This paper	GEO: GSE178929
Published code	This paper	Zenodo: https://doi.org/10.5281/zenodo.7468729
Experimental models: Organisms/strains
CD-1® IGS Mouse	Charles River	Crl: CD1(ICR)
C57BL/6J mouse (JAX™)	Jacksons Lab	JAX: 000664
Software and algorithms
Image J	NIH	https://imagej.nih.gov/ij/download.html
Zeiss Axiovision	Carl Zeiss Microscopy	https://carl-zeiss-vision-axiovision-viewer.software.informer.com/4.8/
UltraVox XT	Noldus	https://www.noldus.com/ultravox-xt
Ethovision XT	Noldus	https://www.noldus.com/ethovision-xt
R studio	Posit	https://posit.co/
Pycharm	Jetbrains	https://www.jetbrains.com/pycharm/
Graphpad	Prism	https://www.graphpad.com/scientific-software/prism/