Figure 2.

Echocardiography evaluation prior to treatment initiation. M-mode images were used to measure parameters at the end of both systole and diastole, including left ventricular posterior wall thickness (A, B), left ventricular end diameter (C, D), left ventricular volume (E, F), ejection fraction (G) and fractional shortening (H) at approximately 28dpi, 53dpi and 70dpi. At each timepoint, infected untreated mice were compared to naïve age matched controls*, p≤0.05; **, p≤0.01; ***, p≤0.001; ****, p≤0.0001.