Table 2.
LVEDs | LVEDd | |||||||
---|---|---|---|---|---|---|---|---|
Days post infection | 72 | 122 | 154 | 208 | 72 | 122 | 154 | 208 |
Naive | 3.081 ± 0.023 | 3.024 ± 0.277 | 3.000 ± 0.400 | 3.048 ± 0.0361 | 3.941 ± 0.195 | 3.969± 0.194 | 4.020± 0.307 | 4.013 ± 0.246 |
Infected untreated | 2.288 ± 0.196 | 2.411 ± 0.527 | 2.542 ± 0.305 | 2.795 ± 0.401 | 3.575 ± 0.100 | 3.672 ± 0.395 | 3.724 ± 0.188 | 3.886 ± 0.347 |
Low BNZ | 2.146 ± 0.573 | 2.643 ± 0.424 | 2.570 ± 0.370 | 2.582 ± 0.294 | 3.425 ± 0.639 | 3.893 ± 0.217 | 3.859 ± 0.322 | 3.825 ± 0.291 |
Low E6020 | 2.569 ± 0.038 | 2.290 ± 0.554 | 2.630 ± 0.326 | 3.081 ± 0.619 | 3.829± 0.334 | 3.570± 0.384 | 3.976± 0.300 $$ | 4.263± 0.599 $$ |
Low Vaccine (sequential) | 2.352 ± 0.543 | 2.624 ± 0.479 | 2.443 ± 0.519 | 2.608 ± 0.226 | 3.789 ± 0.295 | 3.783 ± 0.305 | 3.581 ± 0.311 | 3.723 ± 0.239 |
Low BNZ + Low Vaccine (sequential) | 2.374 ± 0.401 | 2.652 ± 0.621 | 2.753 ± 0.286 * | 2.895 ± 0.351 * | 3.573 ± 0.266 | 3.719 ± 0.317 | 3.915 ± 0.180 ** | 3.959 ± 0.271 * |
Low vaccine (concurrent) | 2.379 ± 0.485 | 2.481 ± 0.487 | 2.694 ± 0.425 | 2.576 ± 0.446 | 3.676 ± 0.323 | 3.712 ± 0.381 | 3.995 ± 0.335 * | 3.819 ± 0.310 |
Low BNZ + Low Vaccine (concurrent) | 2.190 ± 0.539 | 2.497 ± 0.475 | 2.550 ± 0.163 | 2.724 ± 0.393 * | 3.618 ± 0.297 | 3.641 ± 0.183 | 3.761 ± 0.222 | 3.911 ± 0.215 $ |
High E6020 | 2.272 ± 0.395 | 2.634 ± 0.577 | 2.366 ± 0.385 | 2.613 ± 0.541 | 3.507 ± 0.257 | 3.784 ± 0.364 | 3.729 ± 0.248 | 3.723 ± 0.350 |
High Vaccine (sequential) | 2.596 ± 0.343 | 2.633 ± 0.509 | 2.409 ± 0.378 | 2.783 ± 0.363 | 3.725 ± 0.267 | 3.7740± 0.370 | 3.770 ± 0.344 | 3.846 ± 0.220 |
Low BNZ + High Vaccine (sequential) | 2.581 ± 0.279 | 2.563 ± 0.388 | 2.363 ± 0.341 | 2.565 ± 0.378 | 3.768 ± 0.197 | 3.713 ± 0.259 | 3.730 ± 0.228 | 3.797 ± 0.192 |
Curative BNZ | 2.109 ± 0.398 | 2.621 ± 0.384 ** | 2.932 ± 0.400 ** | 3.039 ± 0.341 ** | 3.476 ± 0.269 | 3.695 ± 0.266*** | 4.007 ± 0.271** | 4.093 ± 0.262**$ |
Left ventricular end diameter during systole and diastole. The mean ± SD of LVED was measured from M-mode echocardiography images at the end of systole (LVEDs ) and diastole (LVEDd). When comparing to 72 DPI, *≤0.05, **≤0.01. ***≤0.001. When comparing to 122 DPI, $≤0.05, $$≤0.01.