Figure 3.

Peripheral nervous system changes in Pck2 knockout mice

(A) Sciatic nerve conduction studies of Pck2 knockout mice reveal reduced conduction velocities and temporal dispersion (Table S2) (n = 15 per genotype). Shown are representative tracings from a wild-type littermate and a Pck2 knockout mouse.

(B) Representative semi-thin sections of sciatic nerve. No overt abnormalities were seen, although there was the appearance of an increased proportion of small fibers.

(C) Quantification of axon diameter and myelin thickness as represented by frequency distribution plots. Difference in distribution between genotypes was p = 0.0001 (Wilcoxon rank test, n = 8 per genotype with >50 fibers measured per nerve/animal).