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. 2023 Jan 12;22(2):100496. doi: 10.1016/j.mcpro.2023.100496

Fig. 4.

Fig. 4

Depletion of TEADs decreases cellular resistance to DNA damage. A, MDA-MB-231 cells expressing shNTC, shTEADs-1, or shTEADs-2 were treated with increasing doses of γIR for 24 h. Cells were then exchanged into fresh media and incubated for 5 to 6 days before fixation and staining with crystal violet to quantify cell growth. B, quantification of the data represented in (A). C, MDA-MB-231 cells expressing shNTC, shTEADs-1, or shTEADs-2 were treated with increasing concentrations of bleomycin for 24 h. Cells were then exchanged into fresh media and incubated for 5 to 6 days before fixation and staining with crystal violet. D, quantification of the data represented in (C). E, MDA-MB-231 cells expressing shNTC, shTEADs-1, or shTEADs-2 were treated with increasing concentrations of etoposide for 24 h. Cells were then exchanged into fresh media and incubated for 5 to 6 days before fixation and staining with crystal violet. F, quantification of the data represented in (E). shNTC, nontargeting shRNA control; TEADs, TEA domain family members 1 to 4.