Table 2. Psychotic and Negative Symptoms and Global Functional Levels at 1, 2, 5, 10, and 20 Years After Randomization.
| Follow-up | Mean (SE) | Estimated mean difference (95% CI) | P value of difference | |
|---|---|---|---|---|
| OPUS | TAU | |||
| Psychotic symptom dimensiona | ||||
| 1 y | 1.10 (0.08) | 1.40 (0.09) | −0.30 (−0.54 to −0.06) | .02 |
| 2y | 1.04 (0.09) | 1.38 (0.10) | −0.34 (−0.60 to −0.08) | .01 |
| 5 y | 1.39 (0.12) | 1.30 (0.12) | 0.09 (−0.24 to 0.43) | .58 |
| 10 y | 1.17 (0.10) | 1.17 (0.11) | 0.00 (−0.29 to 0.29) | .99 |
| 20 y | 1.35 (0.14) | 1.21 (0.14) | 0.14 (−0.25 to 0.52) | .48 |
| Negative symptom dimensionb | ||||
| 1 y | 1.71 (0.07) | 2.06 (0.07) | −0.35 (−0.53 to −0.16) | .001 |
| 2 y | 1.42 (0.08) | 1.87 (0.08) | −0.45 (−0.67 to −0.23) | .001 |
| 5 y | 1.70 (0.10) | 1.76 (0.10) | −0.06 (−0.34 to 0.23) | .69 |
| 10 y | 1.55 (0.08) | 1.47 (0.08) | 0.08 (−0.14 to 0.29) | .49 |
| 20 y | 1.82 (0.11) | 1.69 (0.11) | 0.13 (−0.18 to 0.44) | .41 |
| GAF functionc | ||||
| 1 y | 51.74 (0.89) | 49.42 (0.93) | 2.32 (−0.21 to 4.85) | .07 |
| 2y | 54.89 (0.98) | 52.23 (1.04) | 2.66 (−0.13 to 5.45) | .06 |
| 5 y | 53.34 (1.24) | 53.28 (1.26) | 0.05 (−3.41 to 3.52) | .98 |
| 10 y | 53.24 (1.15) | 53.97 (1.19) | −0.73 (−3.99 to 2.52) | .66 |
| 20 y | 51.97 (1.40) | 55.69 (1.43) | −3.72 (−7.67 to 0.22) | .06 |