Fig. 2.

Anti-GM-CSF neutralizing auto-Abs. a Anti-GM-CSF auto-Ab titers in plasma from the three patients diluted 1:50, 1:250, and 1:1,000 (red), healthy individuals (black) and two patients previously shown to have anti-GM-CSF (grey) or anti-IFN-γ (black and white) auto-Abs, and an APS-1 patient with auto-Abs against IL-17A, IL-17F, IL-22 IFN-α, and IFN-ω (black). b STAT5 phosphorylation (p-STAT5), assessed by flow cytometry, upon the stimulation with GM-CSF or IL-3 of control PBMCs, in the absence of plasma, or in the presence of a 1:10 dilution of plasma from a healthy individual, or from the patients. NS non-stimulated