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. 2023 Feb 23;20:45. doi: 10.1186/s12974-023-02731-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Subretinal fibrosis in young and aged mice. A Schematic view of the study design. Mice received two laser burns 10 days apart, eyes were collected 30 days after the second laser for immunohistochemistry. B Representative confocal images of RPE/choroid flatmounts stained for collagen-1 from young (2.5-month) and aged (15–16-month) mice. C Quantitative analysis of collagen-1⁺ lesion area in young and aged group. D, E Representative confocal images of retinal cryosections from young (D) and aged mice (E) with subretinal fibrosis stained for CD31 (green) and collagen-III (red). Cell nuclei were stained with DAPI (blue). F Percentage of CD31⁺ blood vessel area in collagen-III⁺ fibrotic lesions of young and aged mice. Mean ± SD, n = 30–40 lesions per group from 8 to 10 eyes in C, n = 22 lesions per group from 5 to 6 eyes, ***p < 0.001, Student t test. Scale bar = 50 µm