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. 2023 Feb 23;8:23. doi: 10.1038/s41541-023-00622-0

Fig. 6. Correlates of humoral responses and viral loads.

Fig. 6

Group 1 (open squares) received three sham doses, Group 2 (solid triangles) received three doses of GBP510-Wu, Group 3 (open diamonds) received two doses of GBP510-Wu and one dose of GBP510-SA, and Group 4 (solid circles) received two doses of GBH510-Wu and one sham dose. A The correlation between week 10 NAbs against WA1/2020 (R = 0.8545, P < 0.0001, two-sided Spearman rank-correlation tests), Beta (R = 0.8663, P < 0.0001, two-sided Spearman rank-correlation tests), and Delta (R = 0.8640, P < 0.0001, two-sided Spearman rank-correlation tests) vs the peak viral loads in the BAL after challenge with Delta SARS-CoV-2. B The correlation between week 10 NAbs against WA1/2020 (R = 0.8573, P < 0.0001, two-sided Spearman rank-correlation tests), Beta (R = 0.8026, P < 0.0001, two-sided Spearman rank-correlation tests), and Delta (R = 0.8931, P < 0.0001, two-sided Spearman rank-correlation tests) vs the peak viral loads in the NS after challenge with Delta SARS-CoV-2. C The correlation between week 10 RBD specific binding antibodies against WA1/2020 (R = 0.8437, P < 0.0001, two-sided Spearman rank-correlation tests), Beta (R = 0.8427, P < 0.0001, two-sided Spearman rank-correlation tests), and Delta (R = 0.8499, P < 0.0001, two-sided Spearman rank-correlation tests) vs the peak viral loads in the BAL after challenge with Delta SARS-CoV-2. D The correlation between week 10 RBD specific binding antibodies against WA1/2020 (R = 0.8616, P < 0.0001, two-sided Spearman rank-correlation tests), Beta (R = 0.8651, P < 0.0001, two-sided Spearman rank-correlation tests), and Delta (R = 0.8641, P < 0.0001, two-sided Spearman rank-correlation tests) vs the peak viral loads in the NS after challenge with Delta SARS-CoV-2.x.