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. 2023 Feb 9;14:1117320. doi: 10.3389/fimmu.2023.1117320

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Copyright © 2023 Ziegler, Fittje, Müller, Ahrenstorf, Hagemann, Hagen, Hess, Niehrs, Poch, Ravichandran, Löbl, Padoan, Brias, Hennesen, Richard, Richert, Peine, Oldhafer, Fischer, Schramm, Martrus, Bunders, Altfeld and Lunemann

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional activity of TIGIT^+/– and DNAM-1^+/– cells. Functional responses of TIGIT^+/– and DNAM-1^+/– CD56^bright ihNK cells, following co-incubation of liver-derived cells with K562 (E:T ratio of 10:1) for 5h at 37°C. Representative flow plots showing distribution of CD107a (top) and TNF-α (bottom) expression on CD56^bright ihNK cells depending on their TIGIT or DNAM-1 expression. Graphs on top showing percentage of CD107a⁺ TIGIT^+/– or DNAM-1^+/–CD56^bright ihNK cells and graphs below showing percentage of TNF-α⁺ TIGIT^+/– or DNAM-1^+/–CD56^bright ihNK cells. Wilcoxon matched-pairs sign rank test was used to determine statistical differences. Each dot represents one donor (n=8).