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. 2023 Feb 9;13:1121399. doi: 10.3389/fcimb.2023.1121399

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Copyright © 2023 Liu, Xie, Chen, He, Yu, Chen, Mao, Liu, Zhang, Chang, Qiao, Ma, Xue, Jin, Guo, Hou and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PICRUSt analysis in the KEGG pathways. Functional predictions for the oral microbiome of the diseased groups and healthy control group. Significant KEGG pathways at level 3 for the oral microbiome of the diseased groups and healthy control group in subgingival plaque samples were identified by STAMP software. Bar chart showing the functional difference (corrected p-value < 0.05) between periodontitis (A), chronic obstructive pulmonary disease (B) and comorbid diseases (C) versus healthy controls. PICRUSt, Phylogenetic Investigation of Communities by Reconstruction of Unobserved States; KEGG, Kyoto Encyclopedia of Genes and Genomes.