Table 4. Characteristics of local recurrence after nipple-sparing mastectomy.
| Second recurrence – after NSM | ||||||
|---|---|---|---|---|---|---|
| Time until the first recurrence after BCS (months) | Time until the second recurrence after NSM (months) |
Age (years) |
Location of the recurrence | New surgery | Pathology | Survival |
| 12 | 9 | 41 | Same breast/other quadrant | Total mastectomy | IDC: bifocal; 4.5 cm and 0.9 cm; grade 3; ER-/PR-/HER2+ |
Alive |
| 27 | 6 | 59 | Same breast/other quadrant | Total mastectomy | DCIS: 2.8 cm; multifocal; grade 3 |
Alive |
| 55 | 41 | 50 | Same breast/other quadrant | Total mastectomy | IDC: 0.9 cm and 1.4 cm; bifocal; grade 3; ER +/PR +/HER2+ |
Alive |
| 75 | 32 | 48 | NAC | BCS | DCIS: multifocal; grade 3 |
Alive |
| 117 | 83 | 50 | Same breast/same quadrant | Total mastectomy | DCIS: multifocal; grade 2 |
Alive |
Abbreviations: BCS, breast-conserving surgery; DCIS, ductal carcinoma in situ; ER, estrogen receptor; HER2, human epidermal growth factor receptor-2; PR, progesterone receptor; IDC, invasive ductal carcinoma; NAC, nipple-areolar complex; NSM, nipple-sparing mastectomy; PR, progesterone receptor.