Chart 1. Previous studies on NSM for local recurrence after BCS.

Authors (year)	Number of patients	Complication rates	Recurrence rates	Survival	Follow-up (months)
Cordeiro et al. (2012) 14	121 patients who underwent NSM after recurrence + RT; 1.578 patients who underwent NSM for early cancer	Flap necrosis: 18% x 7.7%; infection: 8.3% x 4.8%; hematoma: 0.8% x 1.8%	NA	NA	NA
Lam et al. (2015) 15	22	Seroma: 13.6%; bleeding: 45.%; delayed wound healing: 4.5%; infection: 4.5%	LR: 2	NA	NA
Murphy et al. (2017) 13	21	Postoperative, requiring intervention: 2; flap necrosis: 1; seroma: 2	0%	100%	Median: 14.6
Lee et al. (2019) 12	18 patients who underwent NSM after recurrence; 127 patients who underwent NSM for early cancer	Infecion: 5.6% x 3.9%; nipple necrosis: 11.1% x 17.3%	LR: 5.6% x 3.1% Metastasis: 0% x 5.5% Contralateral BC: 5.6% x 0.8%	100% x 97.6%	Mean: 45.5 × 45.3

Abbreviations: BCS, breast-conserving surgery; NA, not applicable; NSM, nipple-sparing mastectomy; RT, radiotherapy; BC, breast cancer; LR, local recurrence.