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Components of PANoptosome and PANoptosis mediated by ZBP1 PANoptosome. (A) Many proteins can participate in the assembly of PANoptosome. The complex induced by different factors may be different, but it generally contains sensors, adapters, and effectors. (B) ZBP1 contains Zα and RHIM domains and is a representative sensor. A variety of proteins form ZBP1 PANoptosome through the interaction between domains, which can trigger the occurrence of PANoptosis.
