Figure 3.

Regulation of ZBP1 PANoptosome formation and downstream effector activity. At the expression level, ZBP1 is affected by RIG1, type I IFN, and IRF1. At the assembly level, ADAR1 limits the interaction between ZBP1 and RIPK3, whereas CASP6 does the opposite. The downstream of ZBP1 PANoptosome, the activities of pyroptosis, apoptosis, and necroptosis executors are affected by many factors. For example, non-structural protein 1 (NS1), matrix protein 2 (M2), and PB1-F2 can affect the activation of the NLRP3 inflammasome.