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. 2023 Feb 9;10:1051491. doi: 10.3389/fmolb.2023.1051491

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Copyright © 2023 Locke and Hoyt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MITRE: multi-institutional TSA amplified multiplexed immunofluorescence reproducibility evaluation. Before mIF technology can potentially be translated into clinical practice, demonstration of the analytical validity and reproducibility of an end-to-end mIF workflow that supports multisite trials and clinical laboratory processes is vital. In this first multisite study, four leading academic medical centers, one pharma company, and Akoya Biosciences assessed the intersite and intrasite reproducibility of a 6-plex 7-color mIF assay. The results of the study show that the PhenoImager HT is the first spatial biology platform to meet reproducibility requirements for clinical applications (Taube et al., 2021).