CENTRAL (CRS)	Cochrane ENT Register (CRS)	MEDLINE (Ovid)
1 MESH DESCRIPTOR Endolymphatic Hydrops EXPLODE ALL AND CENTRAL:TARGET  2 meniere*):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET  3 (endolymphatic near hydrops):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET  4 (labyrinth* near hydrops):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET  5 (labyrinth* near syndrome):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET  6 (aural near vertigo):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET  7 (labyrinth* near vertigo):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET  8 (cochlea near hydrops):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET  9 (vestibular near hydrops):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET  10 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 AND CENTRAL:TARGET	1 MESH DESCRIPTOR Endolymphatic Hydrops EXPLODE ALL AND INREGISTER  2 (meniere*):AB,EH,KW,KY,MC,MH,TI,TO AND INREGISTER  3 (endolymphatic near hydrops):AB,EH,KW,KY,MC,MH,TI,TO AND INREGISTER  4 (labyrinth* near hydrops):AB,EH,KW,KY,MC,MH,TI,TO AND INREGISTER  5 (labyrinth* near syndrome):AB,EH,KW,KY,MC,MH,TI,TO AND INREGISTER  6 (aural near vertigo):AB,EH,KW,KY,MC,MH,TI,TO AND INREGISTER  7 (labyrinth* near vertigo):AB,EH,KW,KY,MC,MH,TI,TO AND INREGISTER  8 (cochlea near hydrops):AB,EH,KW,KY,MC,MH,TI,TO AND INREGISTER  9 (vestibular near hydrops):AB,EH,KW,KY,MC,MH,TI,TO AND INREGISTER  10 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 AND INREGISTER  11 INREGISTER  12 * AND CENTRAL:TARGET  13 #11 NOT #12  14 #10 AND #13	1 exp Endolymphatic Hydrops/  2 meniere*.ab,ti.  3 (endolymphatic adj3 hydrops).ab,ti.  4 (labyrinth* adj3 hydrops).ab,ti.  5 (labyrinth* adj3 syndrome).ab,ti.  6 (aural adj3 vertigo).ab,ti.  7 (labyrinth* adj3 vertigo).ab,ti.  8 (cochlea adj3 hydrops).ab,ti.  9 (vestibular adj3 hydrops).ab,ti.  10 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9  11 randomized controlled trial.pt.  12 controlled clinical trial.pt.  13 randomized.ab.  14 placebo.ab.  15 drug therapy.fs.  16 randomly.ab.  17 trial.ab.  18 groups.ab.  19 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18  20 exp animals/ not humans.sh.  21 19 not 20  22 10 and 21
Embase (Ovid)	Web of Science Core Collection (Web of Knowledge)	Trial Registries
1 exp Meniere disease/  2 meniere*.ab,ti.  3 (endolymphatic adj3 hydrops).ab,ti.  4 (labyrinth* adj3 hydrops).ab,ti.  5 (labyrinth* adj3 syndrome).ab,ti.  6 (aural adj3 vertigo).ab,ti.  7 (labyrinth* adj3 vertigo).ab,ti.  8 (cochlea adj3 hydrops).ab,ti.  9 (vestibular adj3 hydrops).ab,ti.  10 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9  11 Randomized controlled trial/  12 Controlled clinical study/  13 Random$.ti,ab.  14 randomization/  15 intermethod comparison/  16 placebo.ti,ab.  17 (compare or compared or comparison).ti.  18 ((evaluated or evaluate or evaluating or assessed or assess) and (compare or compared or comparing or comparison)).ab.  19 (open adj label).ti,ab.  20 ((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab.  21 double blind procedure/  22 parallel group$1.ti,ab.  23 (crossover or cross over).ti,ab.  24 ((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab.  25 (assigned or allocated).ti,ab.  26 (controlled adj7 (study or design or trial)).ti,ab.  27 (volunteer or volunteers).ti,ab.  28 human experiment/  29 trial.ti.  30 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29  31 (random$ adj sampl$ adj7 ("cross section$" or questionnaire$1 or survey$ or database$1)).ti,ab.  32 comparative study/ or controlled study/  33 randomi?ed controlled.ti,ab.  34 randomly assigned.ti,ab.  35 32 or 33 or 34  36 31 not 35  37 Cross‐sectional study/  38 randomized controlled trial/ or controlled clinical study/ or controlled study/  39 (randomi?ed controlled or control group$1).ti,ab.  40 38 or 39  41 37 not 40  42 (((case adj control$) and random$) not randomi?ed controlled).ti,ab.  43 (Systematic review not (trial or study)).ti.  44 (nonrandom$ not random$).ti,ab.  45 Random field$.ti,ab.  46 (random cluster adj3 sampl$).ti,ab.  47 (review.ab. and review.pt.) not trial.ti.  48 we searched.ab.  49 review.ti. or review.pt.  50 48 and 49  51 update review.ab.  52 (databases adj4 searched).ab.  53 (rat or rats or mouse or mice or swine or porcine or murine or sheep or lambs or pigs or piglets or rabbit or rabbits or cat or cats or dog or dogs or cattle or bovine or monkey or monkeys or trout or marmoset$1).ti. and animal experiment/  54 36 or 41 or 42 or 43 or 44 or 45 or 46 or 47 or 50 or 51 or 52  55 30 not 54  56 10 and 55	# 12 #11 AND #10   Indexes=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH, BKCI‐S, BKCI‐SSH, ESCI, CCR‐EXPANDED, IC Timespan=All years    # 11 TOPIC: ((randomised OR randomized OR randomisation OR randomisation OR placebo* OR (random* AND (allocat* OR assign*) ) OR (blind* AND (single OR double OR treble OR triple) )))   Indexes=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH, BKCI‐S, BKCI‐SSH, ESCI, CCR‐EXPANDED, IC Timespan=All years    # 10 #9 OR #8 OR #7 OR #6 OR #5 OR #4 OR #3 OR #2 OR #1   Indexes=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH, BKCI‐S, BKCI‐SSH, ESCI, CCR‐EXPANDED, IC Timespan=All years    # 9 TOPIC: (vestibular NEAR/3 hydrops)   Indexes=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH, BKCI‐S, BKCI‐SSH, ESCI, CCR‐EXPANDED, IC Timespan=All years    # 8 TOPIC: (cochlea NEAR/3 hydrops)   Indexes=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH, BKCI‐S, BKCI‐SSH, ESCI, CCR‐EXPANDED, IC Timespan=All years    # 7 TOPIC: (labyrinth* NEAR/3 vertigo)   Indexes=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH, BKCI‐S, BKCI‐SSH, ESCI, CCR‐EXPANDED, IC Timespan=All years    # 6 TOPIC: (labyrinth* adj3 vertigo)   Indexes=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH, BKCI‐S, BKCI‐SSH, ESCI, CCR‐EXPANDED, IC Timespan=All years    # 5 TOPIC: (aural NEAR/3 vertigo)   Indexes=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH, BKCI‐S, BKCI‐SSH, ESCI, CCR‐EXPANDED, IC Timespan=All years    # 4 TOPIC: (labyrinth* NEAR/3 syndrome)   Indexes=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH, BKCI‐S, BKCI‐SSH, ESCI, CCR‐EXPANDED, IC Timespan=All years    # 3 TOPIC: (labyrinth* NEAR/3 hydrops)   Indexes=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH, BKCI‐S, BKCI‐SSH, ESCI, CCR‐EXPANDED, IC Timespan=All years    # 2 TOPIC: (endolymphatic NEAR/3 hydrops)   Indexes=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH, BKCI‐S, BKCI‐SSH, ESCI, CCR‐EXPANDED, IC Timespan=All years    # 1 TOPIC: (meniere*)   Indexes=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH, BKCI‐S, BKCI‐SSH, ESCI, CCR‐EXPANDED, IC Timespan=All years	Clinicaltrials.gov  menieres or meniere or meniere's | Interventional Studies    ICTRP  Meniere*