Table 2.
Comparison of the level of cell adhesion molecules and selectins in different categories of microvascular complications#.
| Marker | T2D without any complication (Baseline) |
Diabetic neuropathy (Follow-up) |
Diabetic retinopathy (Follow-up) |
Diabetic nephropathy (Follow-up) |
Microvascular complications (Follow-up) |
|---|---|---|---|---|---|
| Median (IQR) | (n=27) | Yes (n=36) | Yes (n=42) | Yes (n=49) | Yes (n=63) |
| VCAM-1, ng/ml | 464.87 (371.4 ± 723.25) | 905.75 (652.84 ± 1221.25) ** | 879.23 (669.58 ± 1179.80) ** | 926.72 (688.59 ± 1184.28) ** | 897.33 (670.40 ± 1178.32) ** |
| ICAM-1, ng/ml | 279.47 (196.21 ± 344.02) | 335.52 (237.73 ± 393.55) | 347.58 (279.59 ± 384.37) * | 337.04 (284.20 ± 389.36) ** | 337.04 (277.44 ± 390.66) * |
| E-selectin, ng/ml | 26.58 (20.23 ± 37.89) | 29.88 (20.19 ± 39.11) | 33.40 (22.55 ± 40.32) | 31.83 (21.66 ± 39.30) | 30.54 (21.53 ± 39.28) |
| P-selectin, ng/ml | 204.57 (170.79 ± 244.08) | 231.59 (166.29 ± 293.86) | 243.38 (180.91 ± 305.63) | 250.95 (204.88 ± 325.14) * | 244.22 (197.44 ± 305.20) * |
| L-selectin, ng/ml | 1541.08 (1006.08 ± 1969.42) | 1720.18 (1435.36 ± 1997.85) * | 1765.42 (1402.86 ± 2098.12) * | 1791.08 (1480.40 ± 2149.96) ** | 1791.08 (1458.10 ± 2146.04) ** |
Data represents in median (interquartile range). VCAM-1 (vascular cell adhesion molecule-1), ICAM-1 (intercellular adhesion molecule-1), T2D (type 2 diabetes). Compared between T2D without any complication vs microvascular complications (Yes); T2D without any complication vs diabetic neuropathy (Yes); T2D without any complication vs diabetic retinopathy (Yes); T2D without any complication vs diabetic nephropathy (Yes). *p-value <0.05; ** p-value <0.01. p value <0.05 is statistically significant. ( # comparison of the level of markers of same patients at baseline and follow-up were shown in Supplementary Table 1 ).