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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Small. 2022 Sep 18;18(42):e2204541. doi: 10.1002/smll.202204541

Figure 4. Detection of TSH in diluted goat serum.

Figure 4

(a) Measured SERS spectra using the PRISM assay with an increase of TSH concentration as specified in the figure. Each spectrum was averaged from 5 × 5 spectra collected over a 20 μm × 20 μm area using Raman mapping with a 785 nm excitation laser wavelength. (b) Mapping of the SERS peak wavenumber at 1580 cm−1 with various TSH concentrations as specified. (c) Regression analysis based on the shift of the SERS peak about 1580 cm−1. (d) Correlation between the predicted and the true TSH concentrations in log10 scale. The goat serum matrix was diluted using the TSH calibrator matrix with a ratio of 1:3.