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. 2023 Feb 8;220(4):e20221288. doi: 10.1084/jem.20221288

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Figure 2. — T_N and T_EFF cells form distinct chromatin interaction hubs. (A) Heatmaps showing chromatin interactions in T_N- and T_EFF-specific hubs through Hi-C pile-up analysis centered on hub center and edges in both cell types. (B) Box plots summarizing expression changes of DEGs in T_N- and T_EFF-specific hubs. (C) Box plots summarizing binding strength changes of differential CTCF binding sites in T_N- and T_EFF-specific hubs. The box center lines denote the median, box edge denotes interquartile range (IQR), and whiskers denote the most extreme data points that are no more than 1.5 × IQR from the edge. P values were determined with one-sided Mann–Whitney U test. (D) Heatmaps showing ChrInt among +/−500 kb regions centered on the T_EFF-lost, T_EFF-acquired, and motif⁺ invariant (fold change ≤1.1) CTCF binding sites, based on pile-up analysis of Hi-C data in T_N and T_EFF cells, where color scale denotes ChrInt strength.