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. 2023 Feb 8;220(4):e20221288. doi: 10.1084/jem.20221288

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Figure 3. — CTCF redistribution is associated with genomic architectural changes in T_EFF cells. (A and C) Diamond graphs showing ChrInt in T_N (top) and T_EFF cells (bottom) surrounding cytotoxic effector genes (Ifng, Ccl, and Tbx21 in A) or memory precursor–associated genes (Ccr7, Il7r, and Foxp1 in C) gene loci, as displayed on WashU epigenome browser. Blue boxes denoting ChrInt “patches” showing marked changes between T_N and T_EFF cells. Shown in the middle are gene size and transcription orientation along with CTCF CUT&RUN tracks in T_N and T_EFF cells. (B and D) Network view of T_EFF-specific hubs harboring Ifng, Ccl, and Tbx21 genes (B) and T_N-specific hubs harboring Ccr7, Il7r, and Foxp1 genes (D). Filled nodes represent 10 kb bins belonging to the network community underlying the hub, while open nodes belong to +/−100 kb extended genomic regions from the hub. Gray lines denote increased (B) or decreased (D) ChrInt in T_EFF compared to T_N cells, with line width representing log₂ fold change of ChrInt between T_EFF and T_N cells.