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[Preprint]. 2023 Feb 13:2023.02.13.528372. [Version 1] doi: 10.1101/2023.02.13.528372

Figure 2. Alzheimer’s disease (AD) risk alleles are enriched in the BHLHE41 and SPI1/PU.1 cistromes.

Figure 2.

A) −log10 of enrichment P-values obtained from stratified LD Score Regression (LDSC) analysis of AD GWAS SNP heritability partitioned by transcription factor (TF) proxy-binding sites, which were obtained by stratifying ATAC-Seq peaks in human microglia by the presence of binding motifs for each candidate LAM TF listed on the x-axis. B) −log10 of enrichment P-values obtained from stratified LDSC analysis of AD GWAS SNP heritability partitioned by TF proxy-binding sites, which were obtained by stratifying ATAC-Seq peaks in human monocyte-derived macrophages by the presence of binding motifs for each candidate LAM TF listed on the x-axis. Bars in dark blue or dark red indicate significant enrichments (FDR Adj.P-value < 0.05), bars in light red indicate nominally significant enrichments (P-value < 0.05), while gray bars indicate non-significant enrichments.