Figure 1: The MPC inhibitor 7ACC2 reduces hepatic stellate cell activation in vitro.

Hepatic stellate cells (HSC) were isolated from wild-type Mpc2^fl/fl mice and cultured for up to 7 days (d7) with or without the addition of vehicle (DMSO) or 7ACC2 (1 μM). A portion were harvested after 1 day of culture (non-treated, NT d1) for quiescent HSC. Gene expression was measured by qRT-PCR and data are expressed as mean ± SEM, relative to d1 HSC. *p<0.05, **p<0.01.