Skip to main content
[Preprint]. 2023 Aug 25:2023.02.13.528384. Originally published 2023 Feb 14. [Version 2] doi: 10.1101/2023.02.13.528384

Fig. 5: Lrat-Mpc2−/− mice are protected from MASH-inducing diet.

Fig. 5:

At about 8 weeks of age, littermate wild-type (WT) and Lrat-Mpc2−/− (KO) mice were placed on either a low-fat diet (LFD) or a diet high in fat, fructose, and cholesterol (HFC) for a period of 12 weeks. a,b, Terminal body weight, expressed as total mass (a) and percent body weight gain from initiation of diet (b). c, Liver weight measured at sacrifice, expressed as percent body weight. c,d, Body composition determined by EchoMRI for both (c) fat mass and (d) lean mass, represented as percent body weight. f, Plasma levels of circulating transaminases ALT and AST collected at sacrifice. g, Representative liver sections with H&E staining and immunofluorescence staining for hepatic stellate cells (Desmin), macrophages (F4/80), and nuclei (DAPI). h, Quantification of desmin staining. i, Hepatic gene expression measured by RT-qPCR and expressed relative to WT LFD control group. All data expressed as mean ± SEM (n=7–11/group). *p<0.05, **p<0.01.