Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 8;220(4):e20220538. doi: 10.1084/jem.20220538

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 Scheid et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure S3. — Genes that are higher expressed among PCs from inflamed tissue. (A) Dot plot showing the relative expression of the significantly differentially expressed genes when comparing PCs derived from inflamed tissue with PCs from HCs (x axis) across all subjects and disease states (y axis; pseudobulk DE analysis, FDR < 0.05). Each dot encodes both the detection rate and average gene expression in detected cells for a gene in a cluster. As indicated, dark red color indicates higher average gene expression from the cells in which the gene was detected, and larger dot diameter indicates that the gene was detected in a greater proportion of cells from the cluster. (B) Dot plot showing the relative expression of the antigen presentation genes (x axis) in PCs derived from tissue in different disease states as indicated (y axis). Color and size coding as in A. (C) UMAP plot showing the cell embeddings based on the transcriptome. Cells are colored based on their antigen presentation genes’ expression scores (Materials and methods), where PCs highlighted in dark red show the highest levels of expression. (D) Dot plot showing the relative expression of chemokine receptor genes (x axis) in PCs derived from tissue in different isotypes and disease states as indicated (y axis). Color and size coding as in A and B.