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[Preprint]. 2023 Feb 15:rs.3.rs-2489562. [Version 1] doi: 10.21203/rs.3.rs-2489562/v1

Figure 1. RNA sequencing analyses.

Figure 1

(A) A total of 360 DEGs were obtained between HES1 (+) group (n=5) and HES1 (−) group (n=5) (p<0.05), of which 248 DEGs were downregulated and 112 DEGs were upregulated in HES1 (−) group. (B) The biological pathways implicated by the aberrant HES1 expression revealed by GSEA analysis of the DEGs of HES1 (+) and HES1 (−) groups. (C) GSEA plots showing that HES1 loss was positively correlated with “EPITHELIAL_MESENCHYMAL_TRANSITION” signaling, but negatively correlated with “E2F_TARGETS” and “G2M_CHECKPOINT” signaling.