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[Preprint]. 2023 Feb 15:rs.3.rs-2489562. [Version 1] doi: 10.21203/rs.3.rs-2489562/v1

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(A) Volcano plot identified 93 DEGs between HES1 (+) (n=5) and HES1 (−) group (n=4) (p<0.05), of which 82 DEGs were upregulated and 19 DEGs were downregulated in HES1 (−) group. (B) A heatmap of 52 matrix remodeling and metastasis process-related genes (rows) is shown for 9 samples (columns) including HES1 (−) (blue bar) and HES1 (+) cases (red bar). (C) A heatmap of 46 differentially expressed genes included in the cell proliferation process (rows) for 9 samples (columns) including HES1 (−) (blue bar) and HES1 (+) cases (red bar). (D) The GSVA plot showing that loss of HES1 was positively correlated with the matrix remodeling and metastasis process and negatively correlated with cell proliferation process (* p<0.05).