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[Preprint]. 2023 Feb 15:rs.3.rs-2489562. [Version 1] doi: 10.21203/rs.3.rs-2489562/v1

Figure 6. Signaling pathways involved in higher M2 macrophage in HES1-loss KRAS mutant CRC.

Figure 6

(A-B) “IL6_JAK_STAT3” signaling activation in HES1(−) group was identified by GSEA analysis of TCGA data set(A) and RNA sequencing (B). (C) The expression of phospho-STAT3 was evaluated by IHC, which displayed nuclear staining. Numbers of phospho-STAT3 (+) cases was higher in HES1 (−) group than in HES1 (+) group. (D-E) Expression of M2 macrophage related cytokine, IL10, was assessed by RNA array (* p<0.05) and RNA sequencing (D) as well as by IHC (E).