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. 2022 Jan 10;2:100023. doi: 10.1016/j.dadr.2022.100023

Table 1.

Factors associated with comparative harm of cigarettes vs. nicotine e-cigarettes.



Which Is More Harmful: Cigarettes or Nicotine E-cigarettes?a
All(N = 222) Cigarettes are More Harmful than E-cigarettes(N = 120, 58%)a Nicotine E-Cigarettes are More Harmful or As Harmful as Cigarettes(N = 87, 42%)a Bivariate P valueb IRR (95% CI)
Demographic factors

 Age, years (M±SD) 46 ± 11.4 44 ± 11.2 48 ± 11.3 0.017 1.00 (0.99–1.01)
 Female (vs. Male) 108 (49%) 52 (43%) 52 (60%) 0.020 1.14 (0.91–1.44)
 Hispanic, Latino or Spanish origin 24 (11%) 10 (8%) 12 (14%) 0.21
 Race 0.048
  White 186 (84%) 103 (86%) 72 (83%) 1.00 (0.73–1.38)
  Black 11 (5%) 5 (4%) 4 (5%) Ref
  Other single race 12 (5%) 2 (2%) 8 (9%)
  Multi-race 13 (6%) 10 (8%) 3 (3%)
 Educationc 0.84
  > High school 110 (50%) 61 (51%) 43 (49%)
  ≤ High school or equivalent 111 (50%) 59 (49%) 44 (51%)
Substance Use & Treatment

Cigarette Smoking (past 30d) 0.049
  Yes 160 (72%) 91 (76%) 55 (63%) 0.94 (0.70–1.27)
  No 62 (28%) 29 (24%) 32 (37%) Ref
E-cigarette Vaping (past 30d) <0.001
  Yes 69 (31%) 54 (45%) 12 (14%) 0.80 (0.50–1.28)
  No 153 (69%) 66 (55%) 75 (86%) Ref
Dual use (cigarettes and e-cigarettes) (past 30d) <0.001
  Yes 49 (22%) 40 (33%) 6 (7%) 0.95 (0.54–1.66)
  No 173 (78) 80 (67%) 81 (93%) Ref
Nicotine Use (past 30d) <0.001
 Cigarette only 111 (50%) 51 (43%) 49 (56%)
 Nicotine e-cigarette only 20 (9%) 14 (12%) 6 (7%)
 Dual use 49 (22%) 40 (33%) 6 (7%)
 No use 42 (19%) 15 (13%) 26 (30%)
Buprenorphine (Bup) Treatment
 Bup dose (mg), M±SD 17 ± 7.0 19 ± 6.4 16 ± 7.3 0.002 0.99 (0.98–1.01)
 Years in current bup treatment, M±SD 2.9 ± 1.34 3.1 ± 1.3 2.8 ± 1.4 0.12 0.97 (0.89–1.06)

Note. Tabled values represent N (column percent) unless otherwise noted and percent's may not add to 100% due to rounding. E-cigarette, electronic cigarette. BUP, buprenorphine. Mg, milligrams. D, day. M, mean. SD, standard deviation. CI, confidence interval. IRR, Incidence rate ratio. Ref, reference group. Race was dichotomized in multivariate analyses (i.e., white vs. all other races).

a

Response options included tobacco cigarettes are more harmful, nicotine e-cigarettes are more harmful, both are equally harmful, neither are harmful, and don't know. We combined nicotine e-cigarettes are more harmful and both are equally harmful response options into a single category. We excluded the 14 participants who responded “don't know” and the 1 participant who responded “neither are harmful,” and thus present data on 207 of 222 total participants.

b

p values compare cigarette column to nicotine e-cigarette column using chi-squared tests for categorical variables and t-tests for continuous variables.

c

1 participant responded “don't know” and was excluded from analyses.